Fermi's Paradox and it's insights outside of space-time

The jury is still out on the exact probability with which civilizations arise in a galaxy, but Fermi's paradox is a very true, and important question.

After science feels confident on a more precise estimate for the probability of the development of civilization, and we have either: evidence of other civilizations, or a more accurate calculation of what is expected, I believe the results may be used in connection with the Simulation Argument. That is: If we never find extra-terrestrial life, it should a strong argument to believe we are running inside a simulation.

Yes, I am aware fermi's paradox, and the simulation argument are rather orthogonal, but you must accept there is at least SOME interplay here.